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KMID : 1094020210380030115
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Journal of Veterinary Clinics
2021 Volume.38 No. 3 p.115 ~ p.119
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Clinical Features and Prognosis of Corneal Ulcers in Dogs with Chronic Kidney Disease
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Choi Hee-Yeon
Kim Se-Eun
Kim Tae-Hyun
Jang Jae-Young
Hwang Sun-Young
Seo Kang-Moon
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Abstract
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This study was designed to investigate the characteristics of corneal ulcers in dogs with chronic kidney disease (CKD). Medical records of dogs that had been diagnosed with corneal ulcers and chronic kidney disease at Haemaru Referral Animal Hospital between April 1, 2011 and March 31, 2016 were investigated. A control group was randomly selected during the same time period. This group included patients with corneal ulcers but no evidence of systemic disease. The mean healing time of superficial corneal ulcers in the CKD group was 21.0 ± 15.0 days. This was a significantly longer healing time than was observed in the control group (11.0 ± 6.6 days, p = 0.019). The incidence rates of uveitis and keratoconjunctivitis sicca in the CKD group were significantly higher than in the control group (p = 0.000 and p = 0.026, respectively). Additionally, non-healing ulcers had significantly elevated white blood cell counts, while those with healing ulcers had WBC counts within the normal range in CKD group (p = 0.000). This study revealed that corneal ulcers in CKD patients would be delayed epithelial healing process and accompanied by ocular disease which affected to corneal healing compared to non-CKD patients.
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KEYWORD
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chronic kidney disease, corneal ulcer, dog, keratoconjunctivitis sicca, uveitis
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